City of Clarksdale is a government association in Clarksdale, Mississippi. Clarksdale and Coahoma County, Mississippi, are a colorful mix of Delta characters and fascinating places. Discover a hotel where blueswoman Bessie Smith died and John F. Kennedy, Jr. slept. Eat a tamale or dine at a restaurant co-owned and frequented by Morgan Freeman. We're the crossroads of culture and quirkiness with a heavy dose of the blues.